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The approval has to be set from the "set approval limit V2" Page. Select the option "Filter by module" and search the cost center and click on map button to set the approval accordingly. 

No. It can be Inactive only. Please go to Vendor Master / Employee Master and search the Vendor / Employee and edit the same. There is a checkbox "Is Active" Unselect the check box and update the same once approved after that it will be deleted and will show in red color.